Table 2 Genetic mutations linked to hereditary forms of Parkinson’s disease.
From: Protein Aggregation in the Brain: The Molecular Basis for Alzheimer’s and Parkinson’s Diseases
Locus | Protein | Function |
|---|---|---|
PARK1 | α-synuclein | Putative chaperone |
PARK2 | parkin | Ubiquitin E3 ligase |
PARK6 | PINK1 | Putative serine/threonine kinase |
PARK7 | DJ-1 | Putative chaperone |
PARK8 | LRRK2 | Putative serine/threonine and tyrosine kinase |