Table 3 Biological networks ranked by score in kidney tissues from patients with IF/TA.

1

ADCY7, AZGP1, BST2, BTN3A1, C1ORF38, CASP5, CD160, CECR1, CENTD1, DECR1, FGL2, GOT1, GPR109B, GVIN1, HRASLS3, HRSP12, IFI44, IFI44L, IFNG, IGH@, IGHD, IGHG1, IGL2, IGLC1, ISG20, LAMP3, MNDA, OAS3 (includes EG:4940), OASL, RTP4, SAMD9, SLC15A3, SP110, SP140, TRIM22

45

35

Immune response, cell-to-cell signaling and interaction, hematologic system development and function

2

AIM2, ASPM, CLEC2D (includes EG:29121), COL4A6, CUGBP2, CXCR6, CYC1, cytochrome bc1, EEF1D, ERLIN2, FLRT1, HSD17B10, IFI30, KLRB1, LOXL1, MYBL1, NIT1, PDZK1IP1, PGRMC1, PILRA, PLXNC1, PNOC, RAB31, RDH11, SERPINF2, STOML2, TGFB1, TPSAB1, ubiquinol-cytochrome-c reductase, UQCR, UQCRB (includes EG:7381), UQCRC1, UQCRFS1, UQCRH, UQCRQ

40

33

Carbohydrate metabolism, cell signaling, energy production

3

ARHGEF6, CALCR, CD47, CD69, CDKN1B, CLEC2B, COPS8, CTNNA1, CTSH, CYFIP2, DGKA, Dynamin, EPB41L2, EVL, Foxo, FYB, IGHA1, ITGA4, LAMP2, LGALS1, LGALS3, LPXN, MCM5, MCM6, NCK1 (includes EG:4690), NCKAP1, NPAT, PARD3, POU2AF1, PRSS1 (includes EG:5644), SIRPG, SSTR2, STAG2, TFRC, YWHAH

40

33

Cell cycle, cellular development, cellular movement

4

AIFM1, APIP, ARHGDIB, BCL2A1, CASP1, CASP3, Caspase, CCL5, CIDEB, CYBA, Cyba-Ncf1c-Ncf2-Nox-Ncf4, CYBB, CYCS, ENDOG, GNLY, GZMB, GZMK, HSPE1, IFNγ, IL16, MTCH1, NAIP, NCF4, NGFRAP1, PECAM1, PMAIP1, Pmca, PSAP, PYCARD, RAC2, SERPINB9, SRGN, STK3, TPD52L1, TXN2

35

31

Cell death, cancer, free radical scavenging

5

ALDH7A1, CD180, Ciap, CST7, CYLD, FABP5, FAM46A, IGKC, IL-1R/TLR, IL10RA, IL1RL1, Itgal-Itgb2, LSP1, LY86, LY96, MYD88, Myd88-Tlr1-Tlr2, NFkB, PPIF, PRKD2, RHOH, RSAD2, ST18, STK10, TACSTD1, TLR1, TLR2, TLR4, TLR5, TLR7, TLR8, TNFAIP8, TPMT, TRAFD1, UMOD

33

30

Cell signaling, immune response, cell-to-cell signaling and interaction

6

Adenosine-tetraphosphatase, AGT, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5G3, ATP5O, COX17, COX4I1, COX5A, COX5B, COX6A1, COX6B1, COX6C (includes EG:1345), COX7A1, COX7A2, COX7B, COX7C, COX8A, cytochrome c oxidase, ESRRG, IDH2, IDH3A, NADP isocitrate dehydrogenase, PPARGC1A, PRDX3, SDHA, SDHAL1, SDHB, SDHD, succinate dehydrogenase, succinate dehydrogenase (ubiquinone), TNS1

33

30

Carbohydrate metabolism, cell signaling, energy production

7

CCL8, CCR2, CCR5, CD2, CLC, CSF2RA (includes EG:1438), CSF2RB, CXCR4, DDB2, DNAJA3, GBP1, IFI27, IFNα receptor, IFNGR1, IL10RB, IL21R, IL2RB, IL2RG, IRF1, JAK, JAK2, LIFR, NMI, OAS1, PTPN2, PTPN6, PTPRC, SOCS, SOCS2, STAT, STAT1, STAT4, STAT5a/b, UBE1L, WARS

33

30

Cellular growth and proliferation, cellular development, hematologic system development and function

8

AACS, ACSL, ACSL1, ACSL3, ACSL5, BCL11B, CFD, CKB, CYB5A, CYP51A1, CYP7B1, DBI, ESRRA, ETFDH, EZH2, FDX1, GAD, GAD1, Hdac, HDAC9, histone h3, HMG CoA synthase, IKZF1, LPL, MAOB, MEF2C, MTUS1, RPS9, SC4MOL, SC5DL, SMC4, SP3, SREBF1, SUCLG1, WWC1

33

30

Lipid metabolism, small molecule biochemistry, molecular transport

9

3α-Hydroxysteroid dehydrogenase (A-specific), ACTR2, AKR1C1, AKR1C2, AKR1C3, ARHGEF2, Arp2/3, ARPC2, ARPC5, BAG3, CDH11, CTTN, DAPP1, EGF, Erm, F actin, FGR, FSTL1, HCLS1, HSD17B, HSD17B1, HSD17B12, MAP4K1, MARCKS (includes EG:4082), PDCD4, PFKM, PPAP2B, RALGDS, RAP2B, REPS2, SH2B3, TOM1L1, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, TUFM, WAS

31

29

Cellular assembly and organization, endocrine system development and function, lipid metabolism

10

ACAT1, ACAT2, Acetyl-CoA C-acetyltransferase, ARG2, B2M, CSRP2, CTH, EBI2, FXYD5, HADHB, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMGCS1, IRF2, KLRC2, KLRD1, KLRK1, LILRB1, MHC class I, MHC Iα, NDUFB8, PDGF BB, PLK2, RPL13, SFRS7, SLC1A1, SLC2A3, Sphk, Tap, TAP1, TYROBP

31

29

Cell signaling, immune response, cellular growth and proliferation