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Figure 1 | Molecular Medicine

Figure 1

From: Molecular Mediators of Liver Ischemia and Reperfusion Injury: A Brief Review

Figure 1

Ischemia-reperfusion injury in the liver involves the initial production of oxygen-free radicals and damage-associated molecules with the subsequent involvement of various molecular and cellular cascades, including the Toll-like receptor 4 system, heme oxygenase system, and leukocyte-sinusoidal endothelial cross-talk interactions. Activation of downstream mediators enables the balance between pro-inflammatory and anti-inflammatory responses and the transition from innate to adaptive immune response.

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