Figure 1From: Molecular Mediators of Liver Ischemia and Reperfusion Injury: A Brief ReviewIschemia-reperfusion injury in the liver involves the initial production of oxygen-free radicals and damage-associated molecules with the subsequent involvement of various molecular and cellular cascades, including the Toll-like receptor 4 system, heme oxygenase system, and leukocyte-sinusoidal endothelial cross-talk interactions. Activation of downstream mediators enables the balance between pro-inflammatory and anti-inflammatory responses and the transition from innate to adaptive immune response.Back to article page