Table 1 Differentially expressed proteins in pancreatic ductal adenocarcinoma compared with normal pancreas detected by antibody microarray.
From: The Ubiquitin-Proteasome Pathway Mediates Gelsolin Protein Downregulation in Pancreatic Cancer
Upregulated in pancreatic cancer | Downregulated in pancreatic cancer | ||
|---|---|---|---|
Name | Function | Name | Function |
UbcH6 (ubiquitin-conjugating enzyme H6) | E2 ubiquitin-conjugating enzyme | DCC (deleted in colorectal carcinoma) | Tumor suppressor gene |
GABA b R2 (γ-aminobutyric acid type B receptor, subunit 2) | G-protein-coupled receptor 51 | HPV-16 L1 (human papillomavirus type 16 capsid protein L1) | Human papillomavirus type 16 capsid protein L1 |
Plakophilin 2a | Diverse roles in desmosomes and β-catenin signaling | RACK1 (receptor for activated C kinase 1) | Receptor of activated PKC |
Inhibitor 2 | Inhibit the activity of protein phosphatase 1 | Gelsolin | Actin filament regulatory protein |
Nestin | Intermediate filament protein | Rabaptin-5 | Effector of the small GTPase Rab 5 |
ShcC | Shc family protein, regulation of Ras pathway | DBP2 (DEAD box protein 2) | RNA helicase involved in pre-mRNA splicing |
PRK2 (protein-kinase C-related kinase 2) | The Serine/threonine family of protein kinase, PKC subfamily | IKKα/1 (inhibitor of nuclear factor kappa-B kinase α subunit) | Serine/threonine kinase, active NF-kγ |
Neurogenin 3 | Transcription factor, mediate neuronal differentiation | c-Cbl | Proto-oncogene, E3 ubiquitin-protein ligase |
STAT 3 (signal transducer and activator of transcription 3) | Transcription activator | FXR2 (fragile × mental retardation syndrome related protein 2) | RNA binding protein |
NHE-3 (Na+/H+ exchanger 3) | Regulation of Na+/H+ homeostasis | SRP54 (signal recognition particle 54 kDa protein) | Route proteins from the cytosol to the ER |