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Figure 4 | Molecular Medicine

Figure 4

From: Angiogenesis and Diabetes: Different Responses to Pro-Angiogenic Factors in the Chorioallantoic Membrane Assay

Figure 4

Effect of hyperglycemia on ET-1-, ACE-, and VEGF-mediated nodule formation in the CAM assay. Control and glucose-injected animals received a single intravitellus injection of water or glucose 48 h before the grafting of CHO or HEK cells transfected or not with angiogenic factors. Data are expressed as percentage of cell depots that grew and formed a nodule. The number of embryos that received a cell depot was: 37 and 40 for CHO-ET-1; 14 and 12 for CHO-ACE; 11 and 12 for HEK; and 16 and 11 for HEK-VEGF, control (CT, water-injected) and glucose (GLU), respectively. *P < 0.001 and §P = 0.008 for the comparison of CT versus GLU.

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Molecular Medicine

ISSN: 1528-3658