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Figure 3 | Molecular Medicine

Figure 3

From: Pathogenic Autoantibodies in Systemic Lupus Erythematosus Are Derived from Both Self-Reactive and Non-Self-Reactive B Cells

Figure 3

Antigenic reactivity of mutated antibodies in comparison to their unmutated counterparts. The reactivity of three mutated antibodies and their germline counterparts to different antigens was tested by ELISA at 5 µg/mL and three subsequent 1:4 dilutions. Clone 53 from MC Nussenzweig’s laboratory was used as a negative control (dotted lines). Mutated antibodies and unmutated counterparts are shown in the same color (A9: black; B5: red and G3: green). Triangles and squares represent mutated antibodies and their unmutated counterparts, respectively.

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Molecular Medicine

ISSN: 1528-3658