Skip to main content
Figure 4 | Molecular Medicine

Figure 4

From: Estradiol’s Salutary Effects on Keratinocytes Following Trauma-Hemorrhage Are Mediated by Estrogen Receptor (ER)-α and ER-β

Figure 4

Effects of propyl pyrazole (PPT) and diarylpropionitrile (DPN) on production of cytokines IL-6 (A), IL-10 (B), IL-12 (C), and TNF-α (D) by keratinocytes after trauma-hemorrhage. Keratinocytes were isolated from sham animals and trauma-hemorrhage animals treated with vehicle, DPN, PPT or estrogen. The isolated keratinocytes were stimulated with LPS for 24 hr, supernatants were harvested, and IL-6, IL-10, IL-12 and TNF-α levels in the supernatants were analyzed by use of a cytokine bead array. Data are mean ± SEM from six animals in each group. *P < 0.05 compared with all other groups.

Back to article page

Molecular Medicine

ISSN: 1528-3658