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Figure 3 | Molecular Medicine

Figure 3

From: Endogenous Erythropoietin as Part of the Cytokine Network in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Figure 3

HIF-1α expression is induced in EAE. HIF-lα mRNA was measured in the spinal cord of control and C57BL/6 mice with MOG-induced EAE at d 20 after immunization (A), SJL mice with PLP-induced EAE at the peak of the disease, d 14–15 after immunization (B) or C57BL/6 healthy mice 24 h after treatment with phenylhydrazine (PhH; 150 mg/Kg, i.p., panel C). In the same mice, HIF-2α mRNA was also measured (D–F). EPO mRNA levels, expressed as fold induction versus control, are indicated below. Results are the mean ± SEM (n = 5: panels A,B,D,E; n = 4: panels C,F), with individual samples tested in duplicate. *P< 0.05; **P< 0.01; ***P< 0.001 versus control, Student t test.

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