Figure 4

Hierarchical cluster analysis of autoantigen microarray reactivity of CLL mAbs. Results represent a two-dimensional cluster analysis in which CLL mAbs with similar binding patterns were assigned by computational algorithm to adjacent positions. In the second dimension, a similar computational clustering of antigenic reactivities is shown. Heat map: bright red represents highest relative antibody activity level; bright blue the absence of relative activity level. Results denote reactivity with antigens bound by ≥ 3 mAbs.