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Figure 3 | Molecular Medicine

Figure 3

From: Ghrelin Attenuates Brain Injury after Traumatic Brain Injury and Uncontrolled Hemorrhagic Shock in Rats

Figure 3

Effects of ghrelin on morphologic photomicrography of the cortex after TBI and UH. A, photomicrography of a coronal section at the bregma level from a sham-operated rat. B, photomicrography of a coronal section at the level −4 mm from the bregma from a vehicle treated rat at 4 h after TBI and UH. Note that neuronal damage (swollen, shrunk, or dark eosin-stained, and so on) were present at 4 h after TBI + UH. C, photomicrography of a coronal section at the level −4 mm from the bregma from a ghrelin (4 nmol/rat) treated rat at 4 h after TBI and UH. D, photomicrography of a coronal section at the level −4 mm from the bregma from a ghrelin (8 nmol/rat)-treated rat at 4 h after TBI and UH. E, photomicrography of a coronal section at the level −4 mm from the bregma from a ghrelin (16 nmol/rat)-treated rat at 4 h after TBI and UH. F, percentage of damaged neurons in the cortex in sham-operated animals (Sham) and TBI + UH animals treated with normal saline (Vehicle) or ghrelin (Ghrelin) at 4 h after TBI + UH. Data are presented as means ± SE (n = 3) and compared with one-way ANOVA and Student-Newman-Keuls test: *P < 0.05 versus Sham group; #P < 0.05 versus Vehicle group. Original magnification: 400×, Scale bar = 25 µm.

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