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Table 1 Effect of GTS-21 on monocyte cytotoxicity.a

From: The Selective α7 Agonist GTS-21 Attenuates Cytokine Production in Human Whole Blood and Human Monocytes Activated by Ligands for TLR2, TLR3, TLR4, TLR9, and RAGE

LPS, ng/mL

GTS, µmol/L

NIC, µmol/L

% Cytotoxicity, mean ± SEM

P value

10

0

11.8 ± 2.07

 

10

1

13.7 ± 1.3

>0.05

10

10

11.9 ± 2.5

>0.05

10

50

7.9 ± 1.8

>0.05

10

100

11.6 ± 1.3

>0.05

10

100

13.9 ± 1.1

>0.05

  1. aLDH content was measured in cell supernatants and normalized to permeabilized monocytes, which served as 100% cytotoxicity control. GTS-21 and nicotine-treated monocytes were compared with vehicle-treated monocytes.