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Table 2 Patient demographics.

From: The Selective α7 Agonist GTS-21 Attenuates Cytokine Production in Human Whole Blood and Human Monocytes Activated by Ligands for TLR2, TLR3, TLR4, TLR9, and RAGE

Variable

Severe sepsis (n = 11)

Healthy (n = 14)

P value

Sex, n

   

Males

4

5

0.12

Females

7

9

0.12

Age,y

68.7 ± 13.9

42.4 ± 19.5

<0.01

28-Day mortality, n (%)

   

Overall mortality

3 (27)

 

Male mortality

2 (18)

 

Female mortality

1 (9.1)

 

Severity of disease

   

APACHE

15 ± 3.47

 

APS

39 ± 12.4

 

Clinical manifestation, n(%)

   

Pneumonia

6 (54.5)

 

Urosepsis

5 (45.5)

 

Underlying conditions

   

None

4

 

Hypertension

4

 

Diabetes

2

 

Coronary artery disease

3

 

Congestive heart failure

3

 

Chronic obstructive pulmonary disease/asthma

3

 

Acquisition of infection

   

Community

11