Skip to main content

Table 3 Effect of GTS-21 on TNF levels in endotoxin-stimulated whole blood from healthy volunteers and severe sepsis patients.a

From: The Selective α7 Agonist GTS-21 Attenuates Cytokine Production in Human Whole Blood and Human Monocytes Activated by Ligands for TLR2, TLR3, TLR4, TLR9, and RAGE

LPS, ng/mL

Healthy

Severe sepsis

PBS

GTS-21

% Inhibition

PBS

GTS-21

% Inhibition

1

8156 ± 1008

3680 ± 548b

54

4096 ± 911c

2049 ± 526d

49

10

13940 ± 1605

6769 ± 927b

51

5268 ± 1026c

2466 ± 633d

53

100

16760 ± 1789

8788 ± 1271b

47

6006 ± 1431c

2244 ± 433d

62

  1. aWhole blood obtained from healthy donors (n = 14) and from severe sepsis patients (n = 11) on d 1 of hospital admission was stimulated with different endotoxin concentrations plus GTS-21 (100 µmol/L) or PBS. Results expressed as mean ± SEM.
  2. bP < .005 compared with PBS control.
  3. cP < 0.01 compared with healthy individuals.
  4. dP < 0.01 compared with PBS control.
Back to article page

Molecular Medicine

ISSN: 1528-3658