Table 1 Comparison of the three subfamilies of PRRs.
From: Pattern Recognition Receptor-Dependent Mechanisms of Acute Lung Injury
PPRs | Localization | Activators | Adaptor | Signal | Response |
|---|---|---|---|---|---|
TLRs | Cell membrane | Bacteria | MyD88 | NF-κB | Cytokines |
| Â | Â | Viruses | Mal | MAPKs | Chemokines |
| Â | Â | Fungi | Trif | IRFs | Antiviral proteins |
| Â | Â | Protozoa | TRAM | Â | Pro-IL-1, pro-IL-18 |
NLRs | Cytoplasm | Bacteria | MyD88 | Caspase-1 | IL-1, IL-18 |
|  |  |  |  | NF-κB |  |
RLRs | Cytoplasm | Viruses | IFNβ promoter stimulator 1 | IRFs | Antiviral proteins |
|  |  |  |  | NF-κB |  |
| Â | Â | Â | Â | MAPKs | Â |