Figure 1

In vivo toxicity test of TMC. Rats were injected daily with 0.03 or 0.3 mg/kg TMC for 7 d. Peripheral blood was sampled at d 7. (A) Liver function (alkaline (Alk.) phosphatase, ALT, AST), cholesterol and blood glucose levels were tested. (B) Bone marrow function was estimated based on hemoglobin and hematocrit levels, and the number of white blood cells (WBC), red blood cells (RBC) and platelets. (C) Body weights of rat were measured within the injection period of time. *P < 0.05; **P < 0.005. SGPT, serum glutamic pyruvic transaminase; NS, not significant.