Figure 1

(A) CF patients demonstrate elevated gelatinase activity: CF clinical samples on gelatin zymogram with increased 78 kDa band. Each lane represents a separate patient. (B) CF patients have reduced TIMP-1 levels: Sputum from CF patients (n = 9) are measured via ELISA compared with normal nondisease controls (n = 5), ^*P < 0.05. (C) CF patients have an elevated MMP-9/TIMP-1 ratio: Sputum from CF patients (n = 9) MMP-9/TIMP-1 levels are compared with normal nondisease controls (n = 5), ^*P < 0.01.