Skip to main content
Figure 3 | Molecular Medicine

Figure 3

From: Human Neutrophil Elastase-Mediated Cleavage Sites of MMP-9 and TIMP-1: Implications to Cystic Fibrosis Proteolytic Dysfunction

Figure 3

(A) HNE cleaves MMP-9 and produces a specific fragment: Coomassie blue stain of recombinant human MMP-9 (2 µg) (lane 1) with HNE (2 µg) (lane 2) at 15 min (lane 3), 30 min (lane 4), 45 min (lane 5) and 60 min (lane 6) demonstrated the presence of a 78 kDa isoform. (B) Residues of prodomain of MMP-9 cleaved by HNE: Arrows indicate other protease cleavage sites leading to activation. The two residues we found to be cleaved by HNE are also shown.

Back to article page

Molecular Medicine

ISSN: 1528-3658