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Figure 5 | Molecular Medicine

Figure 5

From: Human Neutrophil Elastase-Mediated Cleavage Sites of MMP-9 and TIMP-1: Implications to Cystic Fibrosis Proteolytic Dysfunction

Figure 5

(A) MMP-9 Crystal Structure (RCSB structure IRJ): The red motif represents the MMP-9 prodomain, while the yellow region represents the remainder of MMP-9 molecule. The purple region represents the catalytic site. The green residue (with white circle) shows the HNE cleavage site (Val38-Ala39 and Ala39-Glu40) as determined via mass spec-trometry. (B) MMP-3 interaction with TIMP-1 (RCSB 1009): While the crystal structure for MMP-9/TIMP-1 interaction is not completely known, it is thought to be similar to MMP-3/TIMP-1 interaction. The pink colored molecule is MMP-3 and the light blue colored molecule is TIMP-1. The red amino acid is Thr98, an important amino acid in TIMP-1 recognition of MMPs. HNE cleavage site for TIMP-1 is Val69 (yellow, with white circle) as determined via N-terminal sequencing of TIMP cleavage products.

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