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Figure 1 | Molecular Medicine

Figure 1

From: Plasma Cytokine Profiles in Preprotachykinin-A Knockout Mice Subjected to Polymicrobial Sepsis

Figure 1

Plasma proinflammatory cytokine profile in wild-type and PPTA−/− septic mice. (A) IL-1β; (B) IL-6; (C) IL-12(p40); (D) IL-12(p70); (E) CXCL1; (F) CCL5; (G) GM-CSF; (H) TNF-α; (I) CCL3; (J) CCL11; (K) IL-1α; (L) IL-5; (M) IFN-γ. Cytokine levels in plasma were measured 1, 5, 8 and 24 h after CLP or sham surgery in wild-type and PPTA−/− mice by multiplex immunoassay. Results were expressed as mean ± SEM (n = at least six mice per group). P values were shown for comparison with corresponding sham group. Symbols were used to denote significant differences between groups as a function of time. Key: balb/C sham, open bars; balb/C CLP, outlined diamond bars; PPTA−/− sham, dotted bars; PPTA−/− CLP, small grid bars. *P< 0.001 when compared with the corresponding normal value; **P< 0.05 when compared with the corresponding values of balb/C septic mice at different time points; #P < 0.05 when compared with the corresponding values of PPTA−/− septic mice at different time points; CLP, cecal ligation and puncture; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; IFN-γ, interferon-γ; PPTA, preprotachykinin A; TNF-α, tumor necrosis factor-α.

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