Figure 2

Plasma antiinflammatory cytokine profile in wild-type and PPTA^−/− septic mice. (A) IL-10; (B) IL-13. Cytokine levels in plasma were measured 1, 5, 8 and 24 h after CLP or sham surgery in wild-type and PPTA^−/− mice by multiplex immunoassay. Results were expressed as mean ± SEM (n = at least six mice per group). P values were shown for comparison with corresponding sham group. Symbols were used to denote significant differences between groups as a function of time. Key: balb/C sham, open bars; balb/C CLP, outlined diamond bars; PPTA^−/− sham, dotted bars; PPTA^−/− CLP, small grid bars. *P < 0.001 when compared with the corresponding normal value; **P < 0.05 when compared with the corresponding values of balb/C septic mice at different time points; ^#P < 0.05 when compared with the corresponding values of PPTA^−/− septic mice at different time points; CLP, cecal ligation and puncture; IL, interleukin; PPTA, preprotachykinin A.