Figure 1
From: Attenuation of the Transforming Growth Factor β-Signaling Pathway in Chronic Venous Ulcers
Deregulation of TGFβRI, TGFβRII and TGFβRIII in VUs. (A) Expression levels of TGFβRI, TGFβRII and TGFβRIII by qPCR. Mean values are represented after normalization to the expression level of HPRT1. Error bars indicate mean ± SD. *Statistically significant differences between VUs and healthy skin were defined as P < 0.05 (A). Immunofluorescence microscopy of healthy skin shows TGFβRI staining in the basal layer of epidermis. TGFβRI is absent in VUs (B). TGFβRII is expressed throughout the epidermis of healthy skin, but not in VUs (C). TGFβRIII is downregulated in VUs (D).