Figure 3
From: Attenuation of the Transforming Growth Factor β-Signaling Pathway in Chronic Venous Ulcers
Phosphorylated Smad2 is absent and Smad7 does not contribute to the attenuation of TGFβ signaling in VUs. (A) Immunohistochemistry shows nuclear pSmad2 in basal keratinocytes in healthy skin, in acute wounds immediately upon wounding and in the migrating epithelial tongue 48 h after wounding. In contrast, no nuclear pSmad2 was observed in keratinocytes of VUs. (B) Smad7 is predominantly expressed in the basal layer in healthy skin and at the acute wound edge immediately after wounding. It is upregulated in migrating epithelial tongue 48 h after wounding and downregulated in VUs.