Antithrombotic effect of XNT on rats. FeCl2-induced thrombus weight in WKY and SHR treated with (A) DX600 and (B) XNT. *P < 0.05 (unpaired Student t test). (C) ACE2 activity in thrombi of WKY and SHR treated with either XNT or DX600. *P < 0.05 versus WKY rats, #P < 0.05 versus untreated SHR (one-way ANOVA followed by the Bonferroni posttest). Each column represents mean ± SEM (n = 7 to 9).