Effect of XNT on thrombus development and time for thrombus formation. (A) Representative photomicrographs showing thrombi development in dorsal skin vessels in nude mice recorded by use of intravital microscopy. The upper panel shows thrombi development in a control animal 1, 8 and 12 min after FeCl3 application. The lower panel shows thrombi development in an XNT-treated mouse 1, 8 and 12 min after FeCl3 application. Arrows indicate thrombi. (B) Ratio between thrombi area/vessel area. *P < 0.05 versus XNT treatment (two-way ANOVA followed by the Bonferroni posttest; n = 6 to 7). (C) Time for thrombus formation after FeCl3 application. Each column represents mean ±SEM (n = 6 to 7). *P < 0.05 versus vehicle (unpaired Student t test).