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Table 1 Organ α-gal A activity 26 weeks postinjection (Experiment 1)

From: α-Galactosidase A-Tat Fusion Enhances Storage Reduction in Hearts and Kidneys of Fabry Mice

α-Gal A specific activity (nmol/hr/mg protein)
  Liver Spleen Heart Kidney BMa Brain Lung
PBS (n = 10) 36 ± 3 135 ± 5 12 ± 1 29 ± 3 53 ± 4 33 ± 1 NDb
LV/enGFP (n = 6) 26 ± 4 111 ± 12 13 ± 2 26 ± 4 58 ± 4 (n = 3) 29 ± 3 117 ± 4 (n = 3)
LV/α-gal A (n = 10) 255 ± 26 328 ± 36 31 ± 2 29 ± 2 66 ± 4 (n = 9) 31 ± 1 113 ± 16 (n = 7)
LV/α-gal A-Tat (n = 10) 310 ± 24 238 ± 34c 35 ± 3 33 ± 3 75 ± 5 30 ± 1 121 ± 18 (n = 7)
WTd (n = 10) 421 ± 22 803 ± 53 89 ± 5 249 ± 10 1481 ± 21 713 ± 26 385 ± 65 (n = 3)
  1. aBM, bone marrow.
  2. bND, not done.
  3. cP < 0.05 vs LV/α-gal A group.
  4. dWT, wild type.