From: α-Galactosidase A-Tat Fusion Enhances Storage Reduction in Hearts and Kidneys of Fabry Mice
α-Gal A specific activity (nmol/hr/mg protein) | |||||||
---|---|---|---|---|---|---|---|
Liver | Spleen | Heart | Kidney | BMa | Brain | Lung | |
PBS (n = 10) | 36 ± 3 | 135 ± 5 | 12 ± 1 | 29 ± 3 | 53 ± 4 | 33 ± 1 | NDb |
LV/enGFP (n = 6) | 26 ± 4 | 111 ± 12 | 13 ± 2 | 26 ± 4 | 58 ± 4 (n = 3) | 29 ± 3 | 117 ± 4 (n = 3) |
LV/α-gal A (n = 10) | 255 ± 26 | 328 ± 36 | 31 ± 2 | 29 ± 2 | 66 ± 4 (n = 9) | 31 ± 1 | 113 ± 16 (n = 7) |
LV/α-gal A-Tat (n = 10) | 310 ± 24 | 238 ± 34c | 35 ± 3 | 33 ± 3 | 75 ± 5 | 30 ± 1 | 121 ± 18 (n = 7) |
WTd (n = 10) | 421 ± 22 | 803 ± 53 | 89 ± 5 | 249 ± 10 | 1481 ± 21 | 713 ± 26 | 385 ± 65 (n = 3) |