From: α-Galactosidase A-Tat Fusion Enhances Storage Reduction in Hearts and Kidneys of Fabry Mice
Gb3 levels (nmol/mg protein) | |||||
---|---|---|---|---|---|
Liver | Spleen | Heart | Kidney | Lung | |
PBS | 13.4 ± 0.8 (n = 7) | 18.4 ± 1.8 (n = 4) | 8.8 ± 1.0 (n = 6) | 29.8 ± 1.5 (n = 7) | 59.1 ± 6.5 (n = 7) |
LV/enGFP | 15.4 ± 2.0 (n = 5) | 11.9 ± 1.3 (n = 4) | 5.1 ± 0.5 (n = 3) | 28.6 ± 7.1 (n = 5) | 8.3 ± 1.4b (n = 3) |
LV/α-gal A | 1.0 ± 0.1 (n = 8) | 2.8 ± 1.2 (n = 6) | 1.3 ± 0.1 (n = 7) | 17.2 ± 1.3 (n = 9) | 12.4 ± 2.2 (n = 7) |
LV/α-gal A-Tat | 0.9 ± 0.2 (n = 8) | 3.0 ± 0.6 (n = 8) | 0.8 ± 0.1c (n = 6) | 8.2 ± 1.7d (n = 9) | 10.2 ± 0.7 (n = 7) |
WTe | 0.6 ± 0.2 (n = 5) | 1.3 ± 0.1 (n = 5) | 0.2 ± 0.1 (n = 4) | 4.9 ± 1.6 (n = 5) | 2.3 ± 0.6 (n = 3) |