Figure 4

Proposed biological network of differentially expressed genes in sepsis. By use of PathwayStudio, a pathway network was built for microarray data based on previously reported interactions in the literature. The links and nodes represent literature-based findings. Some of the prominent, differentially expressed genes shared in inflammatory and immune response in sepsis were used to create the network. (A), Wild-type septic mice. (B), PPTA^−/− septic mice. + depicts positive regulation/expression; line ending with I depicts negative regulation/expression. Up- and downregulated genes are indicated in red and green, respectively. IL1RN, interleukin-1 receptor antagonist; S100A9, S100 calcium binding protein A9 (calgranulin B); CAMP, cathelicidin antimicrobial peptide; GRO2, growth-related oncogene 2 (CXCL2); GRO3, growth-related oncogene 3 (CXCL3); PGLYRP peptidoglycan recognition protein; TLR, toll-like receptor; LBP lipopolysaccharide-binding protein; HSP1A, heat shock protein 1A.