Table 2 Differentially expressed genes in wild-type and PPTA^−/− mice 8 h after CLP-induced sepsis, compared with sham-operated mice.

Inflammatory response

Serum amyloid A 3^b

4.21

54.52

Chemokine (C-C motif) ligand 2^b

5.52

54.37

Fc receptor, IgE, high affinity I, γ polypeptide

2.30

7.15

Chemokine (C-X-C motif) ligand 10^b

5.04

12.58

Chemokine (C-C motif) receptor 1

4.66

15.52

Chemokine (C-X-C motif) ligand 1

5.35

37.74

Interleukin-1 receptor antagonist^b

6.23

125.25

Chemokine (C-X-C motif) ligand 2^b

107.41

114.76

CD14 antigen

7.93

13.70

Toll-like receptor 13

3.72

5.52

Chemokine (C-C motif) ligand 4^b

3.55

17.59

Interleukin-1β^b

6.77

8.85

Selectin, platelet

2.57

12.03

Toll-like receptor 2

4.09

6.09

Complement component 5a receptor 1

3.19

6.50

Tumor necrosis factor receptor superfamily, member 1b

2.15

8.14

CD28 antigen

1.87

2.56

Chemokine (C-C motif) ligand 3^b

13.05

73.16

Toll-like receptor 6

2.18

2.68

Tumor necrosis factor receptor superfamily, member 1a

-^c

2.09

Mitogen-activated protein kinase kinase 3

-

2.12

Oxidized low-density lipoprotein (lectin-like) receptor 1

-

5.51

Orosomucoid 1

-

34.00

Signal transducer and activator of transcription 3

-

2.63

Chemokine (C-C motif) receptor 2^b

-

5.26

Chemokine (C-C motif) ligand 22

-

2.83

Fc receptor, IgG, low affinity IIb

-

9.90

Fc receptor, IgG, low affinity III

-

6.59

Toll-like receptor 5

-

−2.24^d

Toll-like receptor 1

-

3.53

CD44 antigen

-

3.62

Signal transducer and activator of transcription 5a

-

2.44

Phospholipase a2, group VII (platelet-activating factor acetylhydrolase, plasma)

-

7.59

Chemotaxis

Chemokine (C-C motif) ligand 9

2.27

10.09

s100 calcium binding protein A8 (calgranulin A)

2.68

-

Formyl peptide receptor 1

9.01

48.18

Chemokine (C-C motif) ligand 17

-

8.49

Chemokine (C-C motif) receptor 5^b

-

14.45

Cysteine-rich protein 61

-

−5.25

Integrin β 2

-

3.68

Interleukin-16

-

3.71

Chemokine (C-C motif) ligand 6

-

3.63

Leukocyte activation

CD80 antigen

3.19

2.60

CD52 antigen

1.92

2.27

Interleukin-12a

-

2.61

Growth arrest and DNA-damage-inducible 45 γ

-

4.21

fas (TNF receptor superfamily member)

-

4.82

CD40 antigen

-

2.10

Response to wounding

Coagulation factor XIII, a1 subunit

2.12

4.17

Gap junction membrane channel protein α 1

-

3.25

Coagulation factor X

-

17.55

Coagulation factor VII

-

2.43

Fibrinogen, γ polypeptide

-

11.57

Response to bacterium

Cathelicidin antimicrobial peptide

5.33

40.93

Peptidoglycan recognition protein 1

4.44

2.26

Lipopolysaccharide-binding protein

-

2.46

Regulation of cellular process

Protein tyrosine phosphatase, nonreceptor type 11

−2.25

-

Matrix metallopeptidase 9

3.48

1.95

Mitogen-activated protein kinase kinase kinase 8

4.01

8.26

Caspase 4, apoptosis-related cysteine peptidase

-

8.62

Heat shock protein 1A

-

−7.87

Interferon regulatory factor 1

-

3.25

Interferon regulatory factor 7

-

2.63

Signal transduction

Interleukin-7 receptor

-

9.81

G protein-coupled receptor 35

2.77

6.49

Rho family GTPase 1

3.24

8.83

Interleukin-1 receptor, type II

8.97

18.83

G protein-coupled receptor 27

2.24

3.49

Interleukin-10 receptor, α

2.06

2.53

Regulator of G protein signaling 1

4.64

8.55

Suppressor of cytokine signaling 3

4.73

10.67

Regulator of G protein signaling 2

2.36

-

Janus kinase 2

-

2.41

Interleukin-17 receptor

-

2.61

Mitogen-activated protein kinase kinase kinase kinase 2

-

−15.93

Phospholipase C, δ 3

-

−2.55

Chemokine (C-X-C motif) receptor 6

-

2.29

Peroxisome proliferator activator receptor δ

-

2.27

Sphingosine kinase 1

-

6.67

Suppressor of cytokine signaling 2

-

2.27

Interleukin-4 receptor, α

-

4.38

Interleukin-8 receptor, β

-

3.05

Neuropilin 1

-

−2.64

Metallothionein 1

2.68

5.58

Plasminogen activator, urokinase receptor

2.47

4.42

Phosphatidylinositol 3-kinase catalytic delta polypeptide

-

3.39

Mitogen-activated protein kinase kinase kinase kinase 5

-

−2.69

Mitogen-activated protein kinase kinase kinase 1

-

2.83

Mitogen-activated protein kinase kinase kinase 6

-

9.08

Mitogen-activated protein kinase 8

-

−4.66

Response to other organism

Neutrophilic granule protein

4.70

27.44

Response to fungus

Pentraxin-related gene

-

11.74

Cytokine- and chemokine-mediated signaling pathway

Colony-stimulating factor 2 receptor, β 1, low-affinity

2.86

10.45

(granulocyte-macrophage)

Leukocyte immunoglobulin-like receptor, subfamily b

2.57

6.62

(with TM and ITIM domains), member 3

Colony-stimulating factor 2 receptor, β 2, low-affinity

-

4.57

(granulocyte-macrophage)

Other

Lipocalin 2

2.66

11.97

Arginase type II

2.10

5.74

Interleukin-1 family, member 9

5.18

19.02

Matrix metallopeptidase 8

9.61

12.30

Interferon-induced transmembrane protein 6

5.61

34.46

s100 calcium binding protein A9 (calgranulin B)

3.19

2.92

Inhibitor of DNA binding 2

-

3.91

Cytokine-inducible SH2-containing protein

-

2.01

Secretory leukocyte peptidase inhibitor

-

3.76

Amphiregulin

-

3.59

Interferon-induced transmembrane protein 2

-

2.51

Mitogen-activated protein kinase kinase kinase 4

-

−3.23

Mitogen-activated protein kinase-activated protein

-

2.36

kinase 3

Mitogen-activated protein kinase kinase kinase 14

-

2.60

Natriuretic peptide receptor 3

-

3.12