Figure 4
From: Factor VII Deficiency Impairs Cutaneous Wound Healing in Mice
FVIIa signaling is specific and does not require subsequent generation of FXa and thrombin in keratinocyte. Expression levels of Egr-1 (A) and MIP-2 (B) in WT keratinocytes either without pretreatment (filled bars), or preincubated with fondaparinux (5 µg/mL, open bars), or lepirudin (4 µg/mL, horizontal striped bars) for 1 h, before (− mFVIIa) and after (+ mFVIIa) addition of 50 nmol/L mFVIIa for 2 h. *P < 0.05, N ≥ 3 for each genotype.