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Figure 3 | Molecular Medicine

Figure 3

From: PPAR Signaling Pathway and Cancer-Related Proteins Are Involved in Celiac Disease-Associated Tissue Damage

Figure 3

Validation by immunoblotting of several proteins differentially expressed in Group A compared with Group B and analysis of IGM, FABP, RAN and PEBP1 expression levels in RF-CD patients. Immunoblotting assay evidences the differential expression of IGM, FABP, RAN and PEBP1 in Group A (lane 1), Group B (lane 2) and in RF-CD patients (lane 3). Vinculin has been used as control for equal loading. Immunoblotting demonstrates the upregulation of IgM and RAN and the downregulation of the PEBP1 and FABP, in Group B compared with Group A, in accordance with the results obtained by 2D-DIGE analysis. In patients with RF-CD, IgMs remained elevated, FABP was reversed toward normalization, RAN was increased while PEBP1 was decreased with respect to both Group A and Group B CD patients. The Figure shows the results of three representative samples, one from each analyzed Group (A, B and RF-CD). Experimental details are described in the materials and method section.

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Molecular Medicine

ISSN: 1528-3658