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Table 3 Identified differentially expressed proteins.

From: PPAR Signaling Pathway and Cancer-Related Proteins Are Involved in Celiac Disease-Associated Tissue Damage

Protein name

Average ratioa

DeCyder P valueb

Spotc

Database accession numberd

MW (kDa)

pI

Matching peptides

Coverage (%)

Identification P value

Ig mu chain C region

2.92

1.93e-4

224

P01871

50

6,4

11

19

1,00E-04

 

3.71

1.18e-4

227

   

10

22

1,20E-02

  

PPAR signaling pathway

     

Phosphoenolpyruvate carboxykinase

−2.92

1.96e-4

288

Q16822

71

7,5

17

22

3,20E-08

 

−3.3

3.55e-5

289

   

19

27

1,00E-08

Hydroxymethylglutaryl-CoA synthase

−3.33

4.49e-6

436

P54868

55

8,7

12

16

1,60E-05

Medium-chain specific acyl-CoA dehydrogenase

−1.52

4.01e-4

476

P11310

47

8,6

15

31

8,10E-07

Fatty acid binding protein

−4.23

2.91e-5

1094

P12104

15

6,6

7

31

1,90E-02

Fatty acid-binding protein

−3.1

3.16e-4

1123

P07148

14

6,6

6

38

3,30E-02

Apolipoprotein C3

−-4.22

1.66e-4

1189

P02656

9

4,7

4

46

9,20E-04

Carbonyl reductase (NADPH) 1

−1.71

4.65e-7

669

P16152

31

8,6

18

72

1,00E-20

 

−2.77

4.65e-7

683

   

13

43

1,00E-06

Retinol binding protein II

−2.99

1.12e-4

1054

P50120

16

5,3

7

42

2,60E-02

 

−2.72

1.93e-4

1057

   

5

35

1,40E-02

  

Protein metabolism

     

Carbamoyl-phosphate synthase

−1.92

7.56e-5

48

P31327

166

6,3

9

5

3,20E-02

 

−2.03

8.78e-5

49

   

16

9

5,10E-06

 

−1.76

1.93e-4

56

   

32

22

2,60E-19

Elongation factor 2

1.53

4.84e-4

134

P13639

96

6,4

16

16

1,00E-08

Tryptophanyl-tRNA synthetase

2.04

1.45e-4

377

P23381

53

5,8

16

28

1,00E-09

Ornithine aminotransferase

−1.84

8.78e-5

479

P04181

49

6,6

10

22

1,90E-04

Aminoacylase-1

−2.07

7.36e-6

487

Q03154

46

5,8

16

38

6,40E-10

Ornithine aminotransferase

−2.27

2.84e-5

488

P04181

49

6,6

16

33

1,00E-09

Ornithine carbamoyltransferase

−-2.08

1.14e-4

563

P00480

36

7,9

12

20

1,50E-04

Proteasome subunit α type-6

1.37

1.41e-3

797

P60900

28

6,3

9

32

5,90E-04

  

Sugar metabolism

     

Sucrase

−1.72

8.48e-5

62

P14410

210

5,4

22

11

6,40E-06

 

−3.43

7.31e-6

67

   

20

9

3,20E-07

Fructose bisphosphate aldolase B

−3.2

3.55e-5

554

P05062

40

8,3

13

29

6,70E-04

Aldose 1-epimerase

−1.57

1.92e-6

581

Q96C23

38

6,2

8

30

1,80E-04

Fructose-1.6-bisphosphatase

−2.96

2.15e-6

582

P09467

37

6,5

16

33

3,20E-13

Aflatoxin B1 aldehyde reductase member 3

−1.37

5.91e-4

620

O95154

37

6,7

14

41

3,20E-07

  

Lipid metabolism

     

Aldo-keto reductase family 1 member B10

−2.97

3.13e-3

605

O60218

36

7,1

7

20

2,50E-02

 

−2.31

2.34e-4

615

   

11

32

4,70E-04

Glycerol-3-phosphate dehydrogenase

−2.39

5.39e-6

623

P21695

38

5,8

11

22

8,00E-07

Hydroxyacyl-coenzyme A dehydrogenase

−1.62

1.04e-4

665

Q16836

33

8,4

14

30

3,20E-07

Dihydroxyacetone kinase

−2.03

2.20e-5

323

Q3LXA3

59

7,6

15

30

3,20E-09

  

Energy production

     

Aconitate hydratase

−1.74

8.48e-5

180

Q99798

86

7,6

22

28

8,10E-09

Cytochrome b5

−2.4

1.57e-5

1004

P00167

11

5

7

79

2,50E-08

  

Detoxification

     

Catalase

−1.39

1.00e-4

337

P04040

60

6,9

15

28

1,60E-08

Sulfotransferase 1A3/1A4

−1.92

1.50e-4

643

P50224

34

5,7

16

56

1,30E-11

Glutathione S-transferase A1

−1.96

3.16e-4

820

P08263

26

8,9

7

21

1,20E-02

  

Cell proliferation/apoptosis

     

GTP-binding nuclear protein Ran

1.91

2.67e-6

814

P62826

25

7,1

11

42

1,30E-08

Phosphatidylethanolamine-binding protein 1

−1.42

1.25e-3

882

P30086

21

7,4

12

56

1,30E-07

Hypotetical protein MGC29506

2.61

3.22e-5

964

Q8WU39

21

5,4

8

28

3,80E-02

Peroxiredoxin-4

1.78

1.50e-4

782

Q13162

31

5,9

8

27

1,10E-03

  

Structural function

     

Villin 1

−1.4

1.93e-4

144

P09327

93

5,9

30

29

3,20E-14

Lamin-A/C

2.25

1.93e-4

221

P02545

74

6,6

28

42

1,30E-12

 

2.3

5.12e-5

229

   

22

36

4,10E-08

Actin beta

−2.55

2.79e-3

522

P60709

40

5,5

17

43

4,10E-13

Actin-related protein 2/3 complex subunit 2

−1.64

2.06e-6

697

O15144

34

6,8

16

34

6,30E-08

  

Purine metabolism

     

Guanine deaminase

−1.27

4.58e-4

451

Q9Y2T3

51

5,4

12

28

9,10E-04

Adenosine deaminase

−1.9

1.25e-3

519

P00813

41

5,6

13

29

2,60E-07

Purine nucleoside phosphorylase

−2.07

2.26e-4

701

P00491

32

6,5

13

35

2,00E-06

  

Other proteins

     

Calcium-activated chloride channel regulator 1

−2.47

3.22e-4

169

A8K7I4

101

5,9

17

14

1,60E-08

Voltage-dependent anion-selective channel protein 1

−1.46

8.48e-5

666

P21796

31

8,6

8

31

1,10E-04

DnaJ homolog subfamily B member 11

1.31

7.56e-5

534

Q9UBS4

41

5,8

10

28

7,00E-05

  1. aStandardized volume ratio of the protein spot, calculated by DeCyder BVA module, between Group B (CD patients with Marsh II–III) and Group A (controls and CD patients with Marsh 0–I) patients.
  2. bt Test P value determined by DeCyder EDA analysis.
  3. cSpot numbers referring to (30).
  4. dProtein accession numbers were derived from UniProtKB/Swiss-Prot database.
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Molecular Medicine

ISSN: 1528-3658