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Table 3 Correlations between mRNA levels of Hedgehog pathway and target genes; P values and correlation coefficients (Spearman rank correlation test).a

From: Gene Expression Profiling of the Hedgehog Signaling Pathway in Human Meningiomas

 

DISP1/D1SP2

PTCH1/PTCH2

SMO

KlF7

STK36

SUFU

GLI2

GLI4

GLIS2

MTSS1

FOXM1

IGF2

HHAT

0.01/0.44

  

1.90E03/0.48

  

2.40E03/0.47

     

PTCH1/PTCH2

 

3.50E03/0.46

          

HHIP

 

2.40E03/0.47

          

GAS1

3.20E05/0.65

 

2.70E04/0.57

2.60E03/0.47

1.30E03/0.5

 

3.50E04/0.56

 

2.10E04/0.58

   

RAB23

 

5.90E04/0.54

 

1.80E03/0.49

 

2.80E03/0.47

  

8.10E04/0.52

   

KIF7

1.10E05/0.51

 

3.10E06 /0.73

   

1.20E06 /0.76

 

6.00E07 /0.78

   
 

2.80E03/0.47

           

STK36

1.10E03/0.51

 

1.70E03/0.49

2.60E05/0.66

  

3.20e04/0.56

7.30E05/0.62

4.00E05/0.64

   

BTRC

   

2.00E03/0.48

 

5.80E04/0.54

 

4.30E03/0.45

 

0.01/0.39

  

GUI1

 

1.20E05/0.68

3.30E03/0.46

0.01/0.41

  

0.01/0.42

 

3.10E04/0.56

   

GLI2

0.01/041

 

4.70E08 /0.85

1.20E06 /0.76

      

0.01/0.42

 

GLI3

  

1.70E03/0.49

   

4.10E03/0.45

 

0.01/0.39

   

GLI4

2.40E04/0 .57

     

0.01/0.39

  

2.10E05/0.66

  

GLIS2

0.01/0.44

7.20E04 /0.53

1.60E06 /0.75

6.00E07 /0.78

  

8.10E06 /0.7

     

FOXM1

  

2.80E03/0.47

   

0.01/0.42

     

SPP1

          

0.01/0.43

1.70E03/0.49

IGF2

  

9.70E04/0.52

2.80E03/0.47

  

9.50E04/0.52

 

3.40E03/0.46

 

2.10E04/0.58

 

CCND2

           

2.20E03/0.66

PTHR1

         

2.30E04/0.57

  
  1. aP values of 0.01 or lower and respective correlation coefficients (in bold) are separated by a slash. The values of DISP1 and DISP2 as well as PTCH1 and PTCH2 are enclosed in the same cell, denoting DISP2 and PTCH2 by Italics. Correlation coefficient values higher than 0.7 are underlined.