Figure 1

Changes in proinflammatory IL-1F cytokine member mRNA levels in hepatic and subcutaneous (Sc.) adipose tissue before and after weight loss induced by bariatric surgery. (A) IL-1α mRNA expression is barely detectable in both liver tissue and subcutaneous adipose tissue. Highest IL-1α mRNA levels are observed in the visceral (visc.) adipose tissue. (B) A significant reduction in both liver and subcutaneous fat IL-1β expression in individual study subjects after weight loss. The relative abundance of IL-1β mRNA is higher in subcutaneous adipose than in the liver and highest in the visceral fat compartment. (C) IL-18 mRNA expression in liver and subcutaneous fat before and after LAGB. Liver IL-18 mRNA levels decline significantly after weight loss. No significant alterations are observed in subcutaneous adipose tissue. IL-18 expression is most pronounced in visceral adipose tissue. (D) NLRP3 expression before and after weight loss. No significant weight loss-related or tissue-specific differences in NLRP3 mRNA expression are identified. Box plots represent values as median (bold horizontal line), 75% confidence interval (box) and minimum and maximum values (whiskers). sign., significant.