Figure 2

Changes in antiinflammatory IL-1F cytokine member mRNA levels in hepatic and subcutaneous (Sc.) adipose tissue before and after weight loss induced by bariatric surgery. (A) Expression of IL-1 receptor antagonist (IL-1Ra) in liver and adipose tissue before and after weight loss. Hepatic IL-1Ra mRNA concentrations significantly fall after weight loss. No such difference is seen in subcutaneous adipose tissue. IL-1Ra mRNA expression is significantly higher in subcutaneous fat and highest in visceral (visc.) adipose tissue compared with hepatic concentrations. (B) Expression analysis of the antiinflammatory cytokine IL-37 in liver and subcutaneous adipose tissue. Although weight loss does not influence hepatic IL-37 expression, we observe a significant increase in subcutaneous adipose tissue IL-37. The difference between subcutaneous and visceral adipose tissue IL-37 expression does not reach statistical significance. Box plots represent values as median (bold horizontal line), 75% confidence interval (box) and minimum and maximum values (whiskers).