|
Cytokines
| | | |
|
TNF
|
Ab against TNF; Ischemia/reperfusion-induced ALI
|
Not protective
|
(96)
|
|
TNF
|
TNF-α-converting enzyme inhibition in acute lung injury induced by endotoxin in the rat
|
Protective
|
(95)
|
|
Chemokines and their receptors
| | | |
|
IL-8
|
Inhibition of IL-8 in acid aspiration-induced ALI in rabbits
|
Protective
|
(72)
|
|
IL-8
|
Inhibition of IL-8; pancreatitis-induced ALI in rabbits
|
Protective
|
(70)
|
|
IL-8
|
Inhibition of IL-8 in oleic acid + endotoxin-induced ALI
|
Protective
|
(73)
|
|
IL-8
|
Inhibition of IL-8 in an ischemia-reperfusion injury
|
Protective
|
(71)
|
|
CXCR2
|
competitive blockade of CXCR2 in hyperoxia-induced ALI in rats
|
Protective
|
(79)
|
|
CXCR2
|
Inhibition of CXCR2 in acute pancreatitis-associated lung injury
|
Protective
|
(76)
|
|
CXCR2
|
Inhibition of CXCR2 in ischemia-reperfusion injury
|
Protective
|
(80)
|
|
CXCR2
|
Inhibition of CXCR2 in a rabbit model of Gram-positive enterotoxemia
|
Protective
|
(211)
|
|
CXCR2
|
Bleomycin-induced ALI
|
Protective
|
(212)
|
|
CXCR2
|
LPS- and acid-induced ALI
|
Protective
|
(75)
|
|
CINC
|
Neutralizing Ab to CINC (cytokine induced neutrophil chemo-attractant; homolog of human GRO-α) in acute pancreatitis-associated lung injury
|
Protective
|
(213)
|
|
Cell adhesion molecules
| | | |
|
P-selectin
|
Inhibition of P-selectin in a burn injury model of ALI in sheep
|
Not protective
|
(39)
|
|
P-selectin
|
Inhibition of P-selectin with Ab in cobra venom factor (CVF)-induced ALI
|
Protective
|
(46)
|
|
P-selectin
|
Inhibition with sialyl Lewis X-oligosaccharide in a LPS-induced ALI in rabbits
|
Protective
|
(44)
|
|
P-selectin
|
Blocking P-selectin in acid aspiration ALI
|
Protective
|
(47)
|
|
E- and L-selectin
|
Sepsis-induced ALI in Yorkshire swine; dual-binding antibody to E- and L-selectin, EL-246
|
Protective
|
(45)
|
|
Integrins (αvβ5 and αvβ6)
|
IL-1β-induced ALI in mice (blocking Ab against avb5 and avb6 integrins)
|
Protective
|
(51)
|
|
β2-integrins (CD11/CD18)
|
Blocking β2-integrins in a transfusion-induced ALI
|
Not protective
|
(38)
|
|
β2-integrins (CD11/CD18)
|
CVF-induced ALI in rats; Ab against CD11 or CD18
|
Protective
|
(55)
|
|
β2-integrins (CD11/CD18)
|
Inhaled LPS
|
Protective
|
(54)
|
|
β2-integrin
|
β2-integrin blockade in Escherichia coli (E. coli)-induced lung injury in mice
|
Protective
|
(56)
|
|
ICAM-1
|
Inhibition of ICAM-1 in CVF-induced ALI; interestingly ICAM1–/– displayed no protective effect
|
Protective
|
(46)
|
|
Granule proteins
| | | |
|
Neutrophil elastase
|
Sivelestat, a specific neutrophil elastase inhibitor; phorbol myristate acetate-induced ALI in conscious rabbits
|
Protective
|
(113)
|
|
Neutrophil elastase
|
Delayed neutrophil elastase inhibition in ALI induced by endotoxin inhalation in hamsters
|
Protective
|
(114)
|
|
Neutrophil elastase
|
ONO-5046, a competitive, reversible, and specific neutrophil elastase inhibitor in ALI induced by air embolism in awake sheep
|
Not protective
|
(115)
|
|
Neutrophil elastase
|
ONO-5046 in ALI-induced by E. coliendotoxin in pigs
|
Protective
|
(116)
|
|
MMP 8
|
Specific MMP-8 inhibitor in ventilator-induced ALI
|
Protective
|
(152)
|
|
MMP 9
|
MMP inhibitor (6-demethyl-6-deoxy-4-dedimethylamino-tetracycline) treatment for 3 d in ventilator-induced lung injury in rats
|
Protective
|
(149)
|
|
Radical release
| | | |
|
NADPH oxidase
|
NADPH oxidase inhibitor apocynin in sepsis-induced lung injury in guinea pigs
|
Protective
|
(206)
|
|
Nitric oxide synthase
|
LPS-induced ALI
|
Protective
|
(207)
|
