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Table 1 Therapeutic inhibition of neutrophil-dependent processes in acute lung injury.

From: Contribution of Neutrophils to Acute Lung Injury

Target molecule Animal model Effect Ref.
Cytokines    
TNF Ab against TNF; Ischemia/reperfusion-induced ALI Not protective (96)
TNF TNF-α-converting enzyme inhibition in acute lung injury induced by endotoxin in the rat Protective (95)
Chemokines and their receptors    
IL-8 Inhibition of IL-8 in acid aspiration-induced ALI in rabbits Protective (72)
IL-8 Inhibition of IL-8; pancreatitis-induced ALI in rabbits Protective (70)
IL-8 Inhibition of IL-8 in oleic acid + endotoxin-induced ALI Protective (73)
IL-8 Inhibition of IL-8 in an ischemia-reperfusion injury Protective (71)
CXCR2 competitive blockade of CXCR2 in hyperoxia-induced ALI in rats Protective (79)
CXCR2 Inhibition of CXCR2 in acute pancreatitis-associated lung injury Protective (76)
CXCR2 Inhibition of CXCR2 in ischemia-reperfusion injury Protective (80)
CXCR2 Inhibition of CXCR2 in a rabbit model of Gram-positive enterotoxemia Protective (211)
CXCR2 Bleomycin-induced ALI Protective (212)
CXCR2 LPS- and acid-induced ALI Protective (75)
CINC Neutralizing Ab to CINC (cytokine induced neutrophil chemo-attractant; homolog of human GRO-α) in acute pancreatitis-associated lung injury Protective (213)
Cell adhesion molecules    
P-selectin Inhibition of P-selectin in a burn injury model of ALI in sheep Not protective (39)
P-selectin Inhibition of P-selectin with Ab in cobra venom factor (CVF)-induced ALI Protective (46)
P-selectin Inhibition with sialyl Lewis X-oligosaccharide in a LPS-induced ALI in rabbits Protective (44)
P-selectin Blocking P-selectin in acid aspiration ALI Protective (47)
E- and L-selectin Sepsis-induced ALI in Yorkshire swine; dual-binding antibody to E- and L-selectin, EL-246 Protective (45)
Integrins (αvβ5 and αvβ6) IL-1β-induced ALI in mice (blocking Ab against avb5 and avb6 integrins) Protective (51)
β2-integrins (CD11/CD18) Blocking β2-integrins in a transfusion-induced ALI Not protective (38)
β2-integrins (CD11/CD18) CVF-induced ALI in rats; Ab against CD11 or CD18 Protective (55)
β2-integrins (CD11/CD18) Inhaled LPS Protective (54)
β2-integrin β2-integrin blockade in Escherichia coli (E. coli)-induced lung injury in mice Protective (56)
ICAM-1 Inhibition of ICAM-1 in CVF-induced ALI; interestingly ICAM1–/– displayed no protective effect Protective (46)
Granule proteins    
Neutrophil elastase Sivelestat, a specific neutrophil elastase inhibitor; phorbol myristate acetate-induced ALI in conscious rabbits Protective (113)
Neutrophil elastase Delayed neutrophil elastase inhibition in ALI induced by endotoxin inhalation in hamsters Protective (114)
Neutrophil elastase ONO-5046, a competitive, reversible, and specific neutrophil elastase inhibitor in ALI induced by air embolism in awake sheep Not protective (115)
Neutrophil elastase ONO-5046 in ALI-induced by E. coliendotoxin in pigs Protective (116)
MMP 8 Specific MMP-8 inhibitor in ventilator-induced ALI Protective (152)
MMP 9 MMP inhibitor (6-demethyl-6-deoxy-4-dedimethylamino-tetracycline) treatment for 3 d in ventilator-induced lung injury in rats Protective (149)
Radical release    
NADPH oxidase NADPH oxidase inhibitor apocynin in sepsis-induced lung injury in guinea pigs Protective (206)
Nitric oxide synthase LPS-induced ALI Protective (207)