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Figure 1 | Molecular Medicine

Figure 1

From: Novel Aspects of Fibrin(ogen) Fragments during Inflammation

Figure 1

Structure of fibrin(ogen) and its cleavage sites. During coagulation, thrombin cleaves fibrinogen releasing the fibrinopeptides A and B (Aα1–16, Bβ1–14) therewith triggering fibrin polymerization. Following proteolysis of fibrin by plasmin generates various fibrin fragments such as D-dimers, D and E fragments, Bβ15–42 and α chain fragments. The scissors mark plasmin cleavage sites, while the knife marks thrombin cleavage sites.

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