High Mobility Group Protein Bl (HMGB1) in Asthma: Comparison of Patients with Chronic Obstructive Pulmonary Disease and Healthy Controls

Table 3 Correlations between HMGB1 concentration and lung function and cells in induced sputum and peripheral blood in all study subjects.

	Index	r _s	P		Index	r _s	P
P-HMGB1	FVC	−0.617	0.000	S-HMGB1	FVC	−0.697	0.000
P-HMGB1	PEF	−0.656	0.000	S-HMGB1	PEF	−0.789	0.000
P-HMGB1	FEV₁	−0.637	0.000	S-HMGB1	FEV₁	−0.791	0.000
P-HMGB1	FEV₁% predicted	−0.602	0.000	S-HMGB1	FEV₁% predicted	−0.755	0.000
P-HMGB1	B-neu%	0.466	0.000	S-HMGB1	S-neu%	0.547	0.000
P-HMGB1	B-neu	0.409	0.001	S-HMGB1	S-neu	0.547	0.000
P-HMGB1	B-mon	0.185	0.051	S-HMGB1	S-mon	0.179	0.033
P-HMGB1	B-eos%	−0.416	0.000	S-HMGB1	S-eos%	−0.095	0.260
P-HMGB1	B-eos	−0.411	0.000	S-HMGB1	S-eos	0.056	0.508
P-HMGB1	S-HMGB1	0.613	0.000

Study subjects (N = 142). Data are Spearman rank correlation coefficients. P-HMGB1, HMGB1 level in plasma; S-HMGB1, HMGB1 level in sputum; FVC, forced vital capacity; PEF, peak expiratory flow; B-neu, neutrophils in peripheral blood; B-mon, macrophages in peripheral blood; B-eos, eosinophils in peripheral blood; S-neu, neutrophils in induced sputum; S-mon, macrophages in induced sputum; S-eos, eosinophils in induced sputum.

ISSN: 1528-3658