Molecular Medicine

Table 4 Correlations between HMGB1 concentration and lung function, cells in induced sputum and peripheral blood and symptom score in asthma and COPD groups.

From: High Mobility Group Protein Bl (HMGB1) in Asthma: Comparison of Patients with Chronic Obstructive Pulmonary Disease and Healthy Controls

	Asthma (n = 61)				COPD (n = 47)
	Index	r _s	P		Index	r _s	P
P-HMGB1	FVC	−0.299	0.019	P-HMGB1	FVC	−0.468	0.001
P-HMGB1	PEF	−0.432	0.001	P-HMGB1	PEF	−0.360	0.013
P-HMGB1	FEV₁	−0.371	0.003	P-HMGB1	FEV₁	−0.337	0.021
P-HMGB1	FEV₁% predicted	−0.289	0.024	P-HMGB1	FEV₁% predicted	−0.222	0.133
P-HMGB1	B-neu%	0.246	0.056	P-HMGB1	B-neu%	0.323	0.027
P-HMGB1	B-neu	0.418	0.001	P-HMGB1	B-neu	0.232	0.117
P-HMGB1	B-mon	0.188	0.146	P-HMGB1	B-mon	0.022	0.881
P-HMGB1	B-eos%	−0.076	0.562	P-HMGB1	B-eos%	−0.460	0.001
P-HMGB1	B-eos	−0.062	0.635	P-HMGB1	B-eos	−0.428	0.003
P-HMGB1	Nighttimescore	0.300	0.019	P-HMGB1	MRC dyspnoea scale	0.021	0.887
P-HMGB1	S-HMGB1	0.341	0.007	P-HMGB1	S-HMGB1	0.172	0.248
S-HMGB1	FVC	−0.466	0.000	S-HMGB1	FVC	−0.355	0.014
S-HMGB1	PEF	−0.468	0.000	S-HMGB1	PEF	−0.613	0.000
S-HMGB1	FEV₁	−0.442	0.000	S-HMGB1	FEV₁	−0.590	0.000
S-HMGB1	FEV₁% predicted	−0.369	0.003	S-HMGB1	FEV₁% predicted	−0.506	0.000
S-HMGB1	S-neu%	−0.012	0.925	S-HMGB1	S-neu%	0.321	0.028
S-HMGB1	S-neu	0.044	0.631	S-HMGB1	S-neu	0.492	0.000
S-HMGB1	S-mon	0.134	0.736	S-HMGB1	S-mon	0.352	0.015
S-HMGB1	S-eos%	−0.023	0.861	S-HMGB1	S-eos%	−0.204	0.169
S-HMGB1	S-eos	0.004	0.978	S-HMGB1	S-eos	−0.057	0.702
S-HMGB1	Nighttime score	0.231	0.073	S-HMGB1	MRC dyspnoea scale	−0.564	0.000

Data are Spearman rank correlation coefficients. P-HMGB1, HMGB1 level in plasma; S-HMGB1, HMGB1 level in sputum; FVC, forced vital capacity; PEF, peak expiratory flow; B-neu, neutrophils in peripheral blood; B-mon, macrophages in peripheral blood; B-eos, eosinophils in peripheral blood; S-neu, neutrophils in induced sputum; S-mon, macrophages in induced sputum; S-eos, eosinophils in induced sputum.

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ISSN: 1528-3658

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