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Figure 3 | Molecular Medicine

Figure 3

From: Expression of a Broad Array of Negative Costimulatory Molecules and Blimp-1 in T Cells following Priming by HIV-1 Pulsed Dendritic Cells

Figure 3

HIV-pulsed DC prime T cells with increased gene and protein expression of LAG-3, TIM-3, BTLA, CD160 and HVEM. Day-8 cocultures were harvested and mRNA was extracted for qPCR or immunophenotyped for surface protein expression. (A) Gene expression values normalized for LAG-3 (P < 0.001), TIM-3 (P < 0.001), BTLA (P = 0.6), CD160 and HVEM from seven separate experiments. (B) LAG-3, TIM-3, BTLA, CD160 and HVEM surface protein expression from one representative experiment. (C) Protein expression values normalized for LAG-3 (P < 0.05). TIM-3 (P < 0.005), BTLA (P = 0.6). CD160 (P < 0.05). and HVEM.

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Molecular Medicine

ISSN: 1528-3658