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Figure 1 | Molecular Medicine

Figure 1

From: Monoclonal Anti-HMGB1 (High Mobility Group Box Chromosomal Protein 1) Antibody Protection in Two Experimental Arthritis Models

Figure 1

HMGB1 neutralization attenuates the course of spontaneous arthritis in DNase II-/-× IFN-IR-/- mice. Prophylactic therapy with anti-HMGB1 mAb 2G7 was initiated at the age of 5 wks in DNase II-/- × IFN-IR-/- mice with intraperitoneal injections every second day for 5 wks. Development of arthritis was significantly attenuated in 2G7-treated mice (n = 9) compared with mice treated with vehicle alone (n = 9). Values are median clinical score, and error bars represent interquartile range. Statistical analysis of clinical arthritis score is based on calculated area under the curve values for individual animals in each group. The differences between animals in the two studied groups were analyzed by a two-tailed, nonparametric Mann-Whitney test.

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