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Table 1 Bacterial loads and cytokine and chemokine levels in lung homogenates.a,b

From: Kinase Activity Profiling of Gram-Negative Pneumonia

 

3 h

6 h

24 h

48 h

CFU/lung

4.6 × 103 ± 2.6 × 103

9.1 × 10 ± 2.7 × 103

3.1 × 104 ± 8.1 × 103

3.5 × 106 ± 1.2 × 106

TNF-α (pg/mL)

501 ± 230

402 ± 110

905 ± 302

1,658 ± 904

IL-1β (pg/mL)

79 ± 54

84 ± 36

414 ± 210

484 ± 66

IL-6 (pg/mL)

159 ± 69

174 ± 45

510 ± 136

1,920 ± 1,631

KC (pg/mL)

1,885 ± 460

2,809 ± 972

9,451 ± 2,614

28,202 ± 781

MIP-2 (pg/mL)

3,325 ± 887

3,237 ± 659

5,459 ± 1,186

9,397 ± 4,807

  1. aAfter inoculation of 104 CFU of K. pneumoniae, both bacterial loads and cytokine and chemokine levels increase with time.
  2. bData are mean ± SD of three mice per time point.
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Molecular Medicine

ISSN: 1528-3658