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Table 1 Bacterial loads and cytokine and chemokine levels in lung homogenates.a,b

From: Kinase Activity Profiling of Gram-Negative Pneumonia

  3 h 6 h 24 h 48 h
CFU/lung 4.6 × 103 ± 2.6 × 103 9.1 × 10 ± 2.7 × 103 3.1 × 104 ± 8.1 × 103 3.5 × 106 ± 1.2 × 106
TNF-α (pg/mL) 501 ± 230 402 ± 110 905 ± 302 1,658 ± 904
IL-1β (pg/mL) 79 ± 54 84 ± 36 414 ± 210 484 ± 66
IL-6 (pg/mL) 159 ± 69 174 ± 45 510 ± 136 1,920 ± 1,631
KC (pg/mL) 1,885 ± 460 2,809 ± 972 9,451 ± 2,614 28,202 ± 781
MIP-2 (pg/mL) 3,325 ± 887 3,237 ± 659 5,459 ± 1,186 9,397 ± 4,807
  1. aAfter inoculation of 104 CFU of K. pneumoniae, both bacterial loads and cytokine and chemokine levels increase with time.
  2. bData are mean ± SD of three mice per time point.