| |
3 h
|
6 h
|
24 h
|
48 h
|
|---|
|
CFU/lung
|
4.6 × 103 ± 2.6 × 103
|
9.1 × 10 ± 2.7 × 103
|
3.1 × 104 ± 8.1 × 103
|
3.5 × 106 ± 1.2 × 106
|
|
TNF-α (pg/mL)
|
501 ± 230
|
402 ± 110
|
905 ± 302
|
1,658 ± 904
|
|
IL-1β (pg/mL)
|
79 ± 54
|
84 ± 36
|
414 ± 210
|
484 ± 66
|
|
IL-6 (pg/mL)
|
159 ± 69
|
174 ± 45
|
510 ± 136
|
1,920 ± 1,631
|
|
KC (pg/mL)
|
1,885 ± 460
|
2,809 ± 972
|
9,451 ± 2,614
|
28,202 ± 781
|
|
MIP-2 (pg/mL)
|
3,325 ± 887
|
3,237 ± 659
|
5,459 ± 1,186
|
9,397 ± 4,807
|
- aAfter inoculation of 104 CFU of K. pneumoniae, both bacterial loads and cytokine and chemokine levels increase with time.
- bData are mean ± SD of three mice per time point.
