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Figure 10 | Molecular Medicine

Figure 10

From: Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat)

Figure 10

LPS-induced IL-1Ra in while blood cultures. Mean ± SEM of IL-1Ra per mL expressed as percent change of basal production (1),212 ± 102 pg/mL) just before a single oral dose. The hours after the dose are indicated under the horizontal axis. The percent change in cytokine levels shown on the y axis are derived from the 24-h cultures of whole blood obtained at each time point shown under the horizontal axis. n = 9 for each group.

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Molecular Medicine

ISSN: 1528-3658