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Figure 4 | Molecular Medicine

Figure 4

From: Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat)

Figure 4

LPS-induced TNFα and IL-1β in whole blood cultures. The percent change in cytokine levels shown on the y axis are derived from 24-h cultures of whole blood obtained at each time point shown under the horizontal axis. (A) Mean ± SEM percent change of TNFs per mL from basal production (mean for group 815 ± 205 pg/mL) just before a single oral dose. (B) IL-1β in the same samples shown in A. Mean ± SEM basal IL-1β for the group was 1,020 ± 525 pg/mL. n = 9 for each group.

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