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Figure 5 | Molecular Medicine

Figure 5

From: Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat)

Figure 5

Production of LPS-induced TNFα and IL-1β per WBC. (A) Mean ± SEM of TNFα expressed as percent change from baseline. The percent change in cytokine levels shown on the y axis are derived from 24-h cultures of whole blood obtained at 12- and 24-h time points. (B) IL-1β in the same samples shown in A. n = 9 in each group.

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