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Figure 6 | Molecular Medicine

Figure 6

From: Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat)

Figure 6

Comparison of a single dose day 1 and day 7 of ITF2357 on LPS-induced IL-1β. The percent change in cytokine levels shown on the yaxis are derived from 24-h cultures of whole blood obtained at each time point shown under the horizontal axis. (A) Mean ± SEM of IL-1β per mL expressed as percent change of basal production (980 ± 325 pg/mL) just before the single oral administration. (B) Mean ± SEM on day 7 of IL-1β after the 7th daily dose of 200 mg. Basal production was 1,144 ± 625 pg/mL. n = 9 for each group.

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Molecular Medicine

ISSN: 1528-3658