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Figure 7 | Molecular Medicine

Figure 7

From: Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat)

Figure 7

LPS-induced IL-6 and IFNγ in whole blood cultures. The percent change in cytokine levels shown on the y axis are derived from 24-h cultures of whole blood obtained at each time point shown under the horizontal axis. (A) Mean ± SEM percent change of IL-6 per mL from basal production (860 ± 356 pg/mL) just before a single oral dose. (B) IFNγ in the same samples shown in A. Mean ± SEM basal IFNγ was 485 ± 137 pg/mL. n = 9 for each group.

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Molecular Medicine

ISSN: 1528-3658