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Figure 4 | Molecular Medicine

Figure 4

From: Cordycepin Blocks Lung Injury-Associated Inflammation and Promotes BRCA1-Deficient Breast Cancer Cell Killing by Effectively Inhibiting PARP

Figure 4

Cordycepin enhances killing of BRCA1-deficient MCF-7 cells in a manner similar to that achieved by the PARP inhibitor TIQ-A. MCF-7 cells were treated with different doses of cordycepin (A) or TIQ-A (B); subsequently, culture media were collected and assessed for LDH activity. Cytotoxicity is expressed as percent of LDH values detected in media of control-untreated cells. ∗Difference from control MCF-7 cells. (C) MCF-7 cells were transiently transfected with siRNA targeting BRCA1 or control siRNA. Cells, cultured in 96-well plates, were then treated with different doses of cordycepin for 24 h (D) or TIQ-A for 48 h (E), after which cell killing was assessed by MTT assay. ∗Difference from similarly treated control siRNA-transfected MCF-7 cells.

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Molecular Medicine

ISSN: 1528-3658