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Figure 1 | Molecular Medicine

Figure 1

From: B-Cell Subsets in the Joint Compartments of Seropositive and Seronegative Rheumatoid Arthritis (RA) and No-RA Arthritides Express Memory Markers and ZAP70 and Characterize the Aggregate Pattern Irrespectively of the Autoantibody Status

Figure 1

PB and SF B-cell subpopulations in RA (AB+ and AB−) and no-RA patients. B-cell analysis was done by flow cytometry. A region was defined around the CD45+ cells, and total B cells were identified on the basis of the expression of the cell surface marker CD19. The B-cell subpopulations were classified according to IgD and CD38 expression (Bm1–Bm5 classification (A)) or IgD and CD27 expression (B) (19,20). As shown in the plots, naive B cells accumulate preferentially in the PB, whereas memory subsets localize in the synovial compartment. The distribution of B-cell subsets was similar in seropositive as well as in seronegative RA patients and in the RA cohort compared with no-RA cohort, both in blood and in the synovial compartments. *P < 0.05, SF versus PB.

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Molecular Medicine

ISSN: 1528-3658