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Table 3 Distribution of B-cell populations in RA patients with diffuse and aggregate patterns of synovitis.

From: B-Cell Subsets in the Joint Compartments of Seropositive and Seronegative Rheumatoid Arthritis (RA) and No-RA Arthritides Express Memory Markers and ZAP70 and Characterize the Aggregate Pattern Irrespectively of the Autoantibody Status

Variables Aggregate phenotype (PB), n = 13 Diffuse phenotype (PB), n = 14 P Aggregate phenotype (SF), n = 13 Diffuse phenotype (SF), n = 14 P
Age (years) 53.4 ± 19.0 55.9 ± 20.9 0.59  
Disease duration (years) 10.7 ± 7.3 5.5 ± 4.6 0.05  
AB+ (%) 46.2 50.0 0.84  
Erythrocyte sedimentation rate       
(mm/first hour) 46.7 ± 24.9 42.1 ± 22.4 0.64  
C-reactive protein (mg/L) 25.9 ± 16.0 43.0 ± 53.2 1.00  
Disease Activity Score 4.1 ± 1.6 3.9 ± 1.6 0.58  
Health Assessment 1.5 ± 0.8 1.3 ± 0.7 0.45  
Questionnaire       
WBC count (μ/μL) 7,066 ± 2,116 9,632 ± 3,161 0.03 16,010 ± 12,740 11,620 ± 12,195 0.34
Lymphocytes (μ/μL) 2,289 ± 854 2,516 ± 1,100 0.74 2,147 ± 1,665 1,165 ± 836 0.21
Lymphocytes (%) 31.9 ± 10.8 29.8 ± 14.3 0.57 22.5 ± 18.7 17.0 ± 13.2 0.58
CD19 (μ/μL) 179 ± 162 228 ± 105 0.34 22 ± 14 9 ± 8 0.06
CD19 (%) 7.4 ± 5.7 8.7 ± 3.7 0.51 1.1 ± 0.5 2.1 ± 3.4 0.46
Bm1 (%) 29.7 ± 16.8 26.3 ± 10.6 1.00 15.0 ± 10.8 30.0 ± 34.3 0.25
Bm2+Bm2′ (%) 20.1 ± 12.8 44.6 ± 18.6 0.02 1.9 ± 0.6 7.0 ± 4.3 0.01
eBm5 (%) 16.0 ± 8.7 10.9 ± 4.7 0.25 14.9 ± 11.0 13.8 ± 8.8 0.89
Bm5 (%) 29.8 ± 22.2 13.3 ± 9.1 0.20 66.6 ± 12.1 44.6 ± 24.5 0.05
Ratio Bm2+Bm2′/eBm5+Bm5 0.9 ± 1.0 2.9 ± 2.7 0.06 0.02 ± 0.01 0.1 ± 0.1 0.01
IgD+/CD27 (%) 37.5 ± 18.1 66.7 ± 17.9 0.02 11.6 ± 5.4 27.0 ± 16.3 0.06
IgD+/CD27+(%) 16.4 ± 13.0 8.9 ± 7.3 0.15 7.8 ± 7.2 9.2 ± 16.7 0.09
IgD/CD27+(%) 31.4 ± 17.5 15.1 ± 6.6 0.12 55.1 ± 12.7 47.8 ± 18.2 0.57
IgD/CD27 (%) 14.7 ± 8.8 12.2 ± 4.3 0.32 25.5 ± 9.4 29.3 ± 19.8 0.78
CD19+/CD27+CD38+ (%) 12.9 ± 9.0 6.7 ± 4.0 0.15 9.0 ± 7.0 6.9 ± 7.2 0.39
CD19+/ZAP70+(%) 7.1 ± 7.0 7.0 ± 4.6 0.53 22.6 ± 19.3 27.5 ± 24.8 0.89
IHC       
CD20, count   88.1 ± 80.4 24.1 ± 17.4 0.09
CD3, count   157.8 ± 46.4 72.1 ± 53.7 0.02
CD68, count   61.6 ± 40.5 35.6 ± 16.9 0.10
CD27, count   128.6 ± 89.3 34.2 ± 29.7 0.01
CD38, count   45.0 ± 27.8 32.9 ± 31.0 0.47
CD138, count   36.5 ± 32.9 21.2 ± 25.3 0.25
  1. Data are mean ± SD.