Table 3 Distribution of B-cell populations in RA patients with diffuse and aggregate patterns of synovitis.
Variables | Aggregate phenotype (PB), n = 13 | Diffuse phenotype (PB), n = 14 | P | Aggregate phenotype (SF), n = 13 | Diffuse phenotype (SF), n = 14 | P |
|---|---|---|---|---|---|---|
Age (years) | 53.4 ± 19.0 | 55.9 ± 20.9 | 0.59 | — | — | |
Disease duration (years) | 10.7 ± 7.3 | 5.5 ± 4.6 | 0.05 | — | — | |
AB+ (%) | 46.2 | 50.0 | 0.84 | — | — | |
Erythrocyte sedimentation rate | ||||||
(mm/first hour) | 46.7 ± 24.9 | 42.1 ± 22.4 | 0.64 | — | — | |
C-reactive protein (mg/L) | 25.9 ± 16.0 | 43.0 ± 53.2 | 1.00 | — | — | |
Disease Activity Score | 4.1 ± 1.6 | 3.9 ± 1.6 | 0.58 | — | — | |
Health Assessment | 1.5 ± 0.8 | 1.3 ± 0.7 | 0.45 | — | — | |
Questionnaire | ||||||
WBC count (μ/μL) | 7,066 ± 2,116 | 9,632 ± 3,161 | 0.03 | 16,010 ± 12,740 | 11,620 ± 12,195 | 0.34 |
Lymphocytes (μ/μL) | 2,289 ± 854 | 2,516 ± 1,100 | 0.74 | 2,147 ± 1,665 | 1,165 ± 836 | 0.21 |
Lymphocytes (%) | 31.9 ± 10.8 | 29.8 ± 14.3 | 0.57 | 22.5 ± 18.7 | 17.0 ± 13.2 | 0.58 |
CD19 (μ/μL) | 179 ± 162 | 228 ± 105 | 0.34 | 22 ± 14 | 9 ± 8 | 0.06 |
CD19 (%) | 7.4 ± 5.7 | 8.7 ± 3.7 | 0.51 | 1.1 ± 0.5 | 2.1 ± 3.4 | 0.46 |
Bm1 (%) | 29.7 ± 16.8 | 26.3 ± 10.6 | 1.00 | 15.0 ± 10.8 | 30.0 ± 34.3 | 0.25 |
Bm2+Bm2′ (%) | 20.1 ± 12.8 | 44.6 ± 18.6 | 0.02 | 1.9 ± 0.6 | 7.0 ± 4.3 | 0.01 |
eBm5 (%) | 16.0 ± 8.7 | 10.9 ± 4.7 | 0.25 | 14.9 ± 11.0 | 13.8 ± 8.8 | 0.89 |
Bm5 (%) | 29.8 ± 22.2 | 13.3 ± 9.1 | 0.20 | 66.6 ± 12.1 | 44.6 ± 24.5 | 0.05 |
Ratio Bm2+Bm2′/eBm5+Bm5 | 0.9 ± 1.0 | 2.9 ± 2.7 | 0.06 | 0.02 ± 0.01 | 0.1 ± 0.1 | 0.01 |
IgD+/CD27− (%) | 37.5 ± 18.1 | 66.7 ± 17.9 | 0.02 | 11.6 ± 5.4 | 27.0 ± 16.3 | 0.06 |
IgD+/CD27+(%) | 16.4 ± 13.0 | 8.9 ± 7.3 | 0.15 | 7.8 ± 7.2 | 9.2 ± 16.7 | 0.09 |
IgD−/CD27+(%) | 31.4 ± 17.5 | 15.1 ± 6.6 | 0.12 | 55.1 ± 12.7 | 47.8 ± 18.2 | 0.57 |
IgD−/CD27− (%) | 14.7 ± 8.8 | 12.2 ± 4.3 | 0.32 | 25.5 ± 9.4 | 29.3 ± 19.8 | 0.78 |
CD19+/CD27+CD38+ (%) | 12.9 ± 9.0 | 6.7 ± 4.0 | 0.15 | 9.0 ± 7.0 | 6.9 ± 7.2 | 0.39 |
CD19+/ZAP70+(%) | 7.1 ± 7.0 | 7.0 ± 4.6 | 0.53 | 22.6 ± 19.3 | 27.5 ± 24.8 | 0.89 |
IHC | ||||||
CD20, count | — | — | 88.1 ± 80.4 | 24.1 ± 17.4 | 0.09 | |
CD3, count | — | — | 157.8 ± 46.4 | 72.1 ± 53.7 | 0.02 | |
CD68, count | — | — | 61.6 ± 40.5 | 35.6 ± 16.9 | 0.10 | |
CD27, count | — | — | 128.6 ± 89.3 | 34.2 ± 29.7 | 0.01 | |
CD38, count | — | — | 45.0 ± 27.8 | 32.9 ± 31.0 | 0.47 | |
CD138, count | — | — | 36.5 ± 32.9 | 21.2 ± 25.3 | 0.25 |