Figure 1

Morphology of carotid artery arteriosclerotic plaque and the efficiency of SP600125 to inhibit JNK at 10 wks after cast placement in ApoE^−/− mice. (A) Representative images from low and undisturbed flow regions in two groups (hematoxylin and eosin staining; 200×). Bar = 200 µm. (B) Quantification of the intima-media ratio obtained by measuring the area confined by the external elastic lamina of the instrumented carotid artery in NS and JNK-I mice. (C) Western blot analysis of JNK protein expression (including p-JNK and t-JNK) for two groups of mice. (D) The activity of JNK (ratio of p-JNK to t-JNK) in different groups. All data are mean ± SD of sections from 15 different animals. undist, undisturbed shear stress; low, low shear stress. ▲P < 0.05 versus undist regions in NS group. *P < 0.05 versus low regions in NS group.